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MDS risk stratification and curative treatment

The Expanding Role of HCT with IPSS-M

Release date: July 31, 2023 

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Target Audience

This educational activity is intended for physicians, nurses, and other members of the health care team who care for patients who may benefit from hematopoietic cell transplantation (HCT).

Program Overview

This webinar will focus on recent advances in the risk stratification of myelodysplastic syndrome (MDS) and the expanding role of allogeneic HCT as the only curative therapy for MDS. With the International Prognostic Scoring System (IPSS) evolving over the last few years from the revised IPSS (IPSS-R) to the inclusion of molecular disease markers (IPSS-M), more patients than before are being identified as having medium to high-risk MDS. This risk classification is one of the main eligibility criteria for the HCT in MDS. Additionally, advances that have greatly expanded the access of HCT to older patients are not necessarily being reflected in HCT referral patterns. Highlighting results from recently published studies on the development of the IPSS-M, referral patterns for HCT in MDS, and the latest consensus guidelines for the use of HCT in MDS treatment from the American Society for Transplantation and Cellular Therapy (ASTCT), our transplant and hematology/oncology panelists will discuss the current state of HCT eligibility and when to consider HCT for patients with MDS. 

During this interactive webinar, our expert transplant and hematology/oncology panelists will discuss implications for practice change in the risk stratification and eligibility of patients with MDS for HCT, as well as ways to improve access to this curative therapy. This discussion will be tailored for hematologists/oncologists who refer out for transplant and cellular therapies as well as for transplant physicians to highlight the role of sharing care to improve patient access and outcomes. 

Learning Objectives

Upon completion of this course, the learners should be able to:

  • Explain the latest consensus treatment recommendations for MDS and indications for HCT
  • Identify referral patterns and challenges in the management and treatment of MDS
  • Discuss advances in MDS risk stratification that expand HCT eligibility 
  • Recognize how advances in HCT facilitate improved survival and preserve quality of life 
  • Describe the role of transplant and hematology/oncology physicians in improving access to HCT for those with MDS


Steven Devine, MD (moderator)
Chief Medical Officer
National Marrow Donor Program® (NMDP)/Be The Match®
Associate Scientific Director

Robert P. Hasserjian, MD
Professor of Pathology
Director, Hematopathology Fellowship, Department of Pathology
Massachusetts General Hospital

Andrew Brunner, MD
Assistant in Medicine, Division of Hematology/Oncology
Massachusetts General Hospital
Assistant Professor
Harvard Medical School

Bart L. Scott, MD 
Professor, Transplantation Program
Clinical Research Division
Fred Hutch Cancer Center

Planning Committee

Alice Houck, MPS
Senior Director of Patient and Health Professional Services
Aplastic Anemia and MDS International Foundation (AAMDSIF)

Anna Cincotta, FNP
Senior Clinical Operations Partner
National Marrow Donor Program (NMDP)/ Be The Match

Samantha Watters, MPH
Research and Education Lead
Community Physician Engagement 
NMDP/Be The Match

Stephen Spellman, MBS
Vice President of Research and Senior Scientific Director
CIBMTR® (Center for International Blood and Marrow Transplant Research®)
NMDP/Be The Match

Instructions for Participation and Requesting Credit

There are no fees for participating and receiving credit for this activity. Successful completion is achieved by reviewing the CE information, completing the pre-test, completing the activity, and completing the post-test and evaluation form. A score of at least 75% on the posttest is required to successfully complete this activity. The participant may take the test until successfully passed.

Credit fulfillment

  • If you are requesting AMA credits, ANCC credits, or a certificate of participation, your certificate will be available for download.

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Accredited Provider

Accredited Provider

This activity is jointly provided by The France Foundation and the National Marrow Donor Program (NMDP)/Be The Match.

Accreditation Statement

In support of improving patient care, this activity has been planned and implemented by The France Foundation and the National Marrow Donor Program (NMDP)/Be The Match. The France Foundation is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Credit Designation


The France Foundation designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The France Foundation designates this activity for 1.0 contact hour.

All other health care professionals completing this course will be issued a statement of participation.

Disclosure Policy

In accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education, The France Foundation (TFF) and the National Marrow Donor Program (NMDP)/Be The Match require that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial entity. TFF and NMDP/Be the Match resolve all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all their educational programs. Furthermore, TFF and NMDP/Be The Match to verify that all scientific research referred to, reported, or used in a CME/CE activity conforms to the generally accepted standards of experimental design, data collection, and analysis. TFF and NMDP/Be The Match committed to providing learners with high-quality CME/CE activities that promote improvements in health care and not those of a commercial interest.

Planning committee members, faculty, reviewers, and activity staff have disclosed the following relevant financial relationships. All relevant financial relationships listed have been mitigated.

Name of Individual Individual’s Role in Activity Name of Commercial Entity Nature of Relationship(s) Mechanism(s) implemented to resolve conflict of interest
Anna Cincotta, FNP Planning Committee, Content Reviewer No relevant financial disclosures NA NA
Heather Stefanksi, MD, PhD Planning Committee, Content Reviewer 1. Novartis 1. Non-CE Consulting The financial relationship with Novartis ended in April 2021.
Heather Tarbox, MPH TFF Staff No relevant financial disclosures NA NA
Jas Chahal, PhD TFF Staff No relevant financial disclosures NA NA
Karla Dawson, MPH NMDP Staff No relevant financial disclosures NA NA
Kelly Wilson, MSN, RN NMDP Staff No relevant financial disclosures NA NA
Mary Horowitz, MD, MS Planning Committee, Faculty 1. Astellas, Gamida Cell Ltd, Genentech, Magenta, OncoImmune 1. Research

The financial relationship with Astella, Genentech, Magenta, and OncoImmune ended prior to June 2022.

Content was reviewed by a non-conflicted member of the planning committee to ensure that it is not commercially biased, was fair-balanced, and is based on scientific evidence and/or clinical reasoning.

Nandita Khera, MD, MPH Planning Committee, Faculty 1. Optum 1. Honoraria The financial relationship with Optum ended prior to June 2022.
Samantha Watters, MPH Planning Committee, Faculty No relevant financial disclosures NA NA
Stephen Spellman, MBS Planning Committee Member, Moderator No relevant financial disclosures NA NA
Vamsi Kota, MD Planning Committee, Faculty 1. Novartis, Pfizer 1. Honoraria Content was reviewed by a non-conflicted member of the planning committee to ensure that it is not commercially biased, was fair-balanced, and is based on scientific evidence and/or clinical reasoning.

Disclosure of Unlabeled Use:

TFF and NMDP/Be The Match require CME faculty (speakers) to disclose when products or procedures being discussed are off label, unlabeled, experimental, and/or investigational, and any limitations on the information that is presented, such as data that are preliminary, or that represent ongoing research, interim analyses, and/or unsupported opinion. Faculty in this activity may discuss information about pharmaceutical agents that is outside of U.S. Food and Drug Administration approved labeling. This information is intended solely for continuing medical education and is not intended to promote off-label use of these medications. TFF and NMDP/Be The Match do not recommend the use of any agent outside of the labeled indications. If you have questions, contact the Medical Affairs Department of the manufacturer for the most recent prescribing information.


TFF and NMDP/Be The Match present this information for educational purposes only. The content is provided solely by faculty who have been selected because of recognized expertise in their field. Participants have the professional responsibility to ensure that products are prescribed and used appropriately on the basis of their own clinical judgment and accepted standards of care. The France Foundation, NMDP/Be The Match, and the commercial supporter(s) assume no liability for the information herein.

Copyright Information

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Contact Information

If you have questions about this CME activity, please contact The France Foundation at 860-434-1650 or info@francefoundation.comPlease review this information, and proceed below 

Watch the on-demand webinar


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HCT Consultation Timing Guidelines