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NMDP Advanced Cell Therapy Lab Solutions

Comprehensive ACTL offerings to meet your center’s needs

Whether your internal cell therapy lab needs extra support, or your center doesn't have the advanced cell processing capabilities you need, NMDPSM Advanced Cell Therapy Lab (ACTL) Solutions can help. We've expanded our ACTL offerings by further leveraging the expert processing capabilities of our experienced ACTL partner labs.

NMDP ACTL Solutions products

Through NMDP ACTL Solutions, your transplant center can access high quality processing for HPC(M), HPC(A) and MNC(A) products including:

NMDP ACTL Solutions partners

We partner with experienced FACT and AABB-accredited labs including: 

  • Marcus Center for Cellular Cures (MC3)/Carolinas Cord Blood Bank at Duke University
  • Molecular and Cellular Therapeutics Program, M Health Fairview at the University of Minnesota
  • Vitalant Cellular Therapy Laboratory, Tempe, Ariz.
  • Comprehensive Cell Solutions, part of the New York Blood Center Enterprise

See applicable section below for more information on how to proceed with an ACTL Solutions request.

If you have questions about NMDP ACTL Solutions products, talk to your NMDP clinical operations partner (COP) or contact our NMDP ACTL Solutions team at ACTLSolutions@nmdp.org

Cryopreservation

Cryopreservation through NMDP aims to:

  • Increase donor availability by giving donors, donor centers or registries, apheresis centers and collection centers more flexibility in scheduling the donation date
  • Secure a high-quality graft source for your patient
  • Offer your center a reliable transplant experience with little financial risk

When you utilize ACTL Solutions for cryopreservation, the donor's cells are collected and transported to one of our partner labs. The lab cryopreserves and characterizes the product, then stores it until it ships to your center.

Complete FRM-00406 NMDP Advanced Cell Therapy Lab Solutions Request (Legacy F01158) and submit it to your case manager to request donor product cryopreservation.

Donor product cryopreservation through NMDP reduces your financial risk

There is little financial risk to your center to use our cryopreservation service. Unless noted on the fee schedule and/or notified otherwise prior to product collection, you will not be charged for donor workup, product procurement (collection and courier), or cryopreservation processing, storage, and shipment until after the cryopreserved product has shipped from our partner lab to your center.

In the unlikely event your patient cannot proceed to transplant after product collection, your center will not be responsible for those costs unless notified otherwise prior to collection. We’re reducing your financial risk because we know how critically important it is to meet your transplant timeline.

NMDP stem cell bank

There are times when a patient cannot proceed to transplant after donor cell collection and cryopreservation. If the product remained in storage at the NMDP partner lab and the donor provides consent, the cryopreserved product can be made available to other searching patients in NMDP MatchSource® via the Adult Donor Cryopreserved Product (ADCP) search results list.

Request an ADCP product for a patient by submitting FRM-00398 Adult Donor Cryopreserved Product (ADCP) Shipment Request (Legacy F01149) to your NMDP case manager. The ADCP Instructions document (AID-00252) offers instructions on how to complete and return the form.

Fresh product processing

Fresh product processing is available for red blood cell (RBC) and plasma removal prior to product infusion when the donor and patient have a major ABO incompatibility. It is performed most often on marrow products.

Request fresh product processing by submitting a completed FRM-00406 NMDP Advanced Cell Therapy Lab Solutions Request (Legacy F01158) to your case manager.

CD34+ selection

CD34+ selection is most often requested for:

  • The primary patient graft for graft-versus-host disease (GVHD) prophylaxis
  • A second infusion boost when a patient is experiencing graft failure
  • Enhancing the graft-versus-leukemia (GVL) effect for high-risk patients

CD34+ selection requires your transplant center’s IRB approval in most cases. Review our AID-00434 NMDP Advanced Cell Therapy Lab Solutions CD34+ Selection Toolkit for additional information. Use FRM-00406 NMDP Advanced Cell Therapy Lab Solutions Request (Legacy F01158) to request CD34+ selection of a product.

MNC(A) processing (donor lymphocyte infusions)

You can request MNC(A) processing when you need donor lymphocyte infusion (DLI) aliquots for situations such as:

  • Relapsed disease treatment
  • GVL effect induction
  • Minimal residual disease management

The lab doses DLI aliquots according to physician orders and ships the cryopreserved aliquots to your transplant center.

Submit FRM-00406 NMDP Advanced Cell Therapy Lab Solutions Request (Legacy F01158) to your case manager to request MNC(A) processing.

Custom dosing

When you process cryopreserved or fresh products through NMDP ACTL Solutions, your transplant center can request CD34+ dose-specific aliquots to optimize the product for your patient.

Use FRM-00406 NMDP Advanced Cell Therapy Lab Solutions Request (Legacy F01158) to request custom dosing of a product.

How requesting services through NMDP Advanced Cell Therapy Lab Solutions works

The process starts after you’ve selected a donor for workup. If you would like cryopreservation and/or another product processing service, send the NMDP ACTL Solutions request form to your case manager. Your case manager works with the donor center or registry to confirm collection and that cryopreservation and/or product processing through NMDP ACTL Solutions is an option.

After collection, a courier transports the fresh product to one of our partner labs for processing, product characterization and cryopreservation (if applicable). You receive the product cell counts and characterization results as they become available. Your center receives a final product comprehensive report upon all testing completion.

If the product is cryopreserved, it is held in storage until it is shipped to your center. Fresh products are shipped urgently, using a hand-carried courier, for the soonest possible arrival at your center.

NMDP ACTL Solutions frequently asked questions