This summary reflects the latest donor selection recommendations for allogeneic hematopoietic cell transplant (alloHCT), reflecting evolving strategies in GVHD prophylaxis, search efficiency, and donor prioritization. It highlights key considerations for transplant centers, including guidance for both calcineurin inhibitor (CNI) and post-transplant cyclophosphamide (PTCy) settings. In it you will find a streamlined donor search flowchart and updated criteria for matched unrelated donors, haploidentical donors, and umbilical cord blood units.