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Screening hematopoietic and immune systems

Evaluation

Patient-reported symptoms and signs 

None

Clinical examination 

None

Diagnostic testing

  • Complete blood count and differential
  • Test for presence of autoantibodies
  • Quantitative immunoglobulin levels

Clinical manifestation

Clinical manifestation
Description
Thrombocytopenia**
Persistent decrease in the number of blood platelets; <100,000/μL
Eosinophilia**
Abnormal increase in the number of eosinophils; >500/μL
Lymphopenia**
Reduction in the number of lymphocytes; <500/μL
Hypo- or hyper-gammaglobulinemia**
Deficiency or excess of gamma globulins in the peripheral blood
Autoantibodies**
Autoimmune hemolytic anemia (AIHA). Idiopathic thrombocytopenic purpura (ITP). Autoantibodies may develop, including antinuclear antibody, anti-centromere antibody, anti-mitochondrial antibody, anti-ENA screen, anti-double stranded DNA antibody, anticardiolipin antibody

* Distinctive but insufficient alone to establish an unequivocal diagnosis of chronic GVHD without further testing or additional organ involvement.

** Rare, controversial, or non-specific features of chronic GVHD.

*** Common in both acute and chronic GVHD.