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Screening for other manifestations of chronic GVHD

Evaluation

For these manifestations, chronic GVHD is often a diagnosis of exclusion

Clinical manifestation

Clinical manifestation
Description

Raynaud's phenomenon**

Disruption of blood flow to digits and skin

Pericardial or pleural effusions** Ascites**
Peripheral neuropathy**
Nephrotic syndrome**
Myasthenia gravis**
Cardiac conduction abnormality or cardiomyopathy**

Although these manifestations cannot be used to establish a diagnosis of chronic GVHD, a wide range of organ system manifestations including neurologic complications, nephrotic syndrome and cardiac abnormalities have been described in association with cGVHD and may represent chronic GVHD manifestations. If after careful differential diagnosis no alternative etiologic factor is identified, it may be concluded that these manifestations represent chronic GVHD disease activity.


* Distinctive but insufficient alone to establish an unequivocal diagnosis of chronic GVHD without further testing or additional organ involvement.

** Rare, controversial, or non-specific features of chronic GVHD.

*** Common in both acute and chronic GVHD.