Tools
These web tools are intended for research purposes only. Please exercise caution when making clinical decisions.
For the latest news and tools, visit NMDP Bioinformatics tools.
Search Prognosis
This application enables the ability to assess the efficiency of a search prior to beginning the search process. It uses the patient’s genotype race/ethnicity and frequency to determine a prognosis returned as Good, Fair. or Poor.
B-Leader Assessment Tool (BLEAT)
This web application provides services for classifying the leader peptides (either M or T at position -21) and matching statuses of HLA-B alleles and ranks them based on transplant outcome measures.
PBM Matching Tool
The Class 1 HLA Peptide Binding Motif (PBM) Matching Tool maps Class I HLA typing to PBM groups and calculates the direction of group match or mismatch. Mismatches across PBM groups in the Graft versus Host (GvH) vector (Unidirectional GvH or Bidirectional) are predicted to be less well tolerated than mismatches within the same PBM group or in the Host versus Graft (HvG) vector (PBM matched or Unidirectional HvG).
DPB1 & TCE Prediction Tool
This tool imputes missing HLA-DPB1 TCE (T-Cell Epitope) information by predicting how likely unrelated donors have a permissive match with a patient. The input is an exported donor list from MatchSource which can be predicted, sorted, and filtered based on TCE permissive match probabilities.
DPB1 Expression Tool (ExPAT)
This tool incorporates HLA-DP expression and HLA-DPB1 T-cell epitope (TCE) information and applies to patient and donor allotypes and matches. This tool allows for sorting of the donor list to identify favorable and permissive (mis)matches through two-step and reversible sorting of both expression and TCE models.
MAC Service UI
The MAC Service encodes MACs from compressed allele lists (CAL) and GL strings. Its functions include encoding, looking up, decoding and expanding MACs.
Haploidentical Donor Selector
This tool predicts the probability of disease-free survival from attributes of a hematopoietic stem cell transplant donor-recipient pair based on research findings. This retrospective study of 1434 patients uses a Cox proportional hazards model to better understand the effects of HLA locus-specific risks following haploidentical transplantation using PTCy.
HaploStats (population genetics)
Access frequency information for haplotypes and haplotype pairs relative to specific HLA types found in the U.S. population.
py-ard
py-ard is a suite of tools, a web service and a Python library that understands the panoply of HLA Nomenclature and can validate, expand and transform among them.
GFE
This system describes HLA polymorphism in terms of HLA gene features (GFs). This system enumerates the unique nucleotide sequences for each GF in an HLA gene, and records these in a GF enumeration notation that allows both more granular dissection of allele-level HLA polymorphism and the discussion and analysis of GFs in the absence of ARD-encoding exon sequences.
For the latest news and tools, visit NMDP Bioinformatics tools.
Search & Match
Search Prognosis
This application enables the ability to assess the efficiency of a search prior to beginning the search process. It uses the patient’s genotype race/ethnicity and frequency to determine a prognosis returned as Good, Fair. or Poor.
B-Leader Assessment Tool (BLEAT)
This web application provides services for classifying the leader peptides (either M or T at position -21) and matching statuses of HLA-B alleles and ranks them based on transplant outcome measures.
PBM Matching Tool
The Class 1 HLA Peptide Binding Motif (PBM) Matching Tool maps Class I HLA typing to PBM groups and calculates the direction of group match or mismatch. Mismatches across PBM groups in the Graft versus Host (GvH) vector (Unidirectional GvH or Bidirectional) are predicted to be less well tolerated than mismatches within the same PBM group or in the Host versus Graft (HvG) vector (PBM matched or Unidirectional HvG).
DPB1 & TCE Prediction Tool
This tool imputes missing HLA-DPB1 TCE (T-Cell Epitope) information by predicting how likely unrelated donors have a permissive match with a patient. The input is an exported donor list from MatchSource which can be predicted, sorted, and filtered based on TCE permissive match probabilities.
DPB1 Expression Tool (ExPAT)
This tool incorporates HLA-DP expression and HLA-DPB1 T-cell epitope (TCE) information and applies to patient and donor allotypes and matches. This tool allows for sorting of the donor list to identify favorable and permissive (mis)matches through two-step and reversible sorting of both expression and TCE models.
MAC Service UI
The MAC Service encodes MACs from compressed allele lists (CAL) and GL strings. Its functions include encoding, looking up, decoding and expanding MACs.
Transplant or Therapy Outcomes
Haploidentical Donor Selector
This tool predicts the probability of disease-free survival from attributes of a hematopoietic stem cell transplant donor-recipient pair based on research findings. This retrospective study of 1434 patients uses a Cox proportional hazards model to better understand the effects of HLA locus-specific risks following haploidentical transplantation using PTCy.
Population & Genetics
HaploStats (population genetics)
Access frequency information for haplotypes and haplotype pairs relative to specific HLA types found in the U.S. population.
py-ard
py-ard is a suite of tools, a web service and a Python library that understands the panoply of HLA Nomenclature and can validate, expand and transform among them.
GFE
This system describes HLA polymorphism in terms of HLA gene features (GFs). This system enumerates the unique nucleotide sequences for each GF in an HLA gene, and records these in a GF enumeration notation that allows both more granular dissection of allele-level HLA polymorphism and the discussion and analysis of GFs in the absence of ARD-encoding exon sequences.