High-resolution HLA alleles and haplotypes in the U.S. population

The high-resolution allele and haplotype frequencies have been updated as of December 2007 and represent an erratum to the original published frequencies. Please download the new frequency tables and updated manuscript tables and figures.

For complete details on this study, read the journal article published in Human Immunology:

High resolution HLA alleles and haplotypes in the United States population

Updated manuscript tables and figures

Table 1 - Definition of alleles identical over antigen binding domain (PDF) Table 2 - Total chromosome counts per allele and haplotype category (PDF) Table 3 - Number of distinct alleles observed (PDF) Table 4 - Hardy-Weinberg test results (PDF) Table 5 - Haplotype sampling statistics (PDF) Table 6 - Top 10 A-B-DRB1 frequencies compared by race/ethnic group (PDF) Figure 1 - Frequency distribution of Top 25 A-B-DRB1 haploytypes (PDF) Figure 2 - Haplotype frequency comparisons with full registry samples (PDF)

Updated high-resolution HLA alleles and haplotype lists for U.S. population

HLA-A	PDF	XLS
HLA-B	PDF	XLS
HLA-DRB1	PDF	XLS
HLA-C	PDF	XLS
HLA-DQB1	PDF	XLS
HLA-A-B	PDF	XLS
HLA-A-B-DRB1	PDF	XLS
HLA-A-B-DRB1-DQB1	PDF	XLS
HLA-A-C-B	PDF	XLS
HLA-A-C-B-DRB1	PDF	XLS
HLA-A-C-B-DRB1-DQB1	PDF	XLS
HLA-B-DRB1	PDF	XLS
HLA-C-B	PDF	XLS
HLA-C-B-DRB1-DQB1	PDF	XLS
HLA-DRB1-DQB1	PDF	XLS

Human Immunology Manuscript Frequencies - 2006

Note: These frequencies are deprecated but match the sample counts from the published September 2007 Human Immunology journal article. Individuals carrying HLA alleles (A*0201g and A*2402g) were systematically excluded from a subset of our population (roughly half of the minority groups: AFA, API, HIS) due to a technical issue with allele ambiguities and our failure to characterize these two allele groups as high-resolution.